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Simultaneous extracellular and intracellular recordings of normal action potentials, action potentials initiated at a time when the membrane was partially depolarized (by premature beats or elevated extracellular potassium), and action potentials at reduced temperature were made for Purkinje strands from the left ventricle of the dog with a 50µ tungsten extracellur electrode and a special guarded intracellular microelectrode. The peak-to-peak amplitude of the extracellular wave form was proportional to the maximum rate of rise of the intracellular action potential, and the duration of the extracellular wave form was proportional of the duration of the upstroke of the intracellular potential. Wave forms of extracellular potentials were computed from the recorded intracellular potentials with an equation which included the effects of membrane currents away from the point of observation. The computed wave forms accurately reproduced the recorded extracellular wave forms in all cases, and the wave forms were not directly porportional to the second spatial derivative or the second temporal derivative of the intracellular potential. Extracellular potentials are shown to be directly related to the spatial distribution of the intracellular potential and as such are a sensitive index of propagation and a source of information of the kind previously thought to be obtainable only with an intracllular electrode.

Extracellular Potentials Related to Intracellular Action Potentials in the Dog Purkinje System