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Acetylstrophanthidin perfused directly into the sinus node artery of the dog decreases the response of the sinus node to adrenergic stimulation. When sinus arrest followed per-fusion of high concentrations of glycosides, either sympathetic stimulation or intranodal epinephrine transiently restored sinus rhythm.

Antagonlstic Effects on the Sinus Node of Acetylstrophanthidin and Adrenergic Stimulation