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1 × 10−6 M Lanatoside C has been demonstrated to produce a sustained increase in oxygen consumption in human myocardial tissue slices as previously demonstrated by Burdette. This acceleration of qO2 is independent of the substrates employed with the exception of succinate. This qO2 acceleration has been demonstrated to be calcium dependent in human heart tissue slices similar to the known interrelationship of calcium and digitalis on myocardial contractility. The observation that the greatest increase in qO2 occurred with glucose and without exogenous substrate suggests that the increase in qO2 induced by the glycoside is dependent upon a stimulatory effect on glycolysis.

Role of Calclum and Lanatoside C in Increasing Oxygen Consumption in Human Myocardial Tissue Slices