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The major problem four years ago was to solve the technical aspects of ureteral catheterization. The difficulties were bladder leakage, inadequate urine flow rates, ureteroreual sympathetic reflexes, postcatheterization morbidity, and a complete lack of criteria for recognizing valid reproducible data. It was clear that, unless these problems were solved first, the functional characterization of a kidney producing human arterial hypertension, as well as the conditions which affected those characteristics, would have to await a different approach. It was equally clear, however, that the normal symmetry of the kidneys in the dog and the human offered an excellent opportunity to examine the function of a kidney responsible for hypertension while the contralateral kidney served as a control.

Functional Characteristics of Renovascular Hypertension with Emphasis on the Relationship of Renal Blood Flow to Hypertension