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To the Editor:I read with great interest the recent report by Schalcher et al, entitled “Interaction of Sildenafil With cAMP-Mediated Vasodilation In Vivo.”1 The data presented deals with a potentially important issue and, given the increasing interest in using phosphodiesterase 5 (PDE5) inhibitors for various conditions, in addition to erectile dysfunction, are also timely. As a researcher studying the role of cyclic nucleotide phosphodiesterases (PDEs) in cardiovascular tissues, I would like to take this opportunity to comment on some of the statements made in the discussion of these data. First, since …

Does Sildenafil Indirectly Inhibit Phosphodiesterase 3 in Vascular Smooth Muscle?