Platelet Activation With Unfractionated Heparin at Therapeutic Concentrations and Comparison With Low-Molecular-Weight Heparin and With a Direct Thrombin Inhibitor | Zendy

Giuseppe Cella | Zendy; Antonio Girolami | Zendy; Arthur A. Sasahara | Zendy

Open Access

Platelet Activation With Unfractionated Heparin at Therapeutic Concentrations and Comparison With Low-Molecular-Weight Heparin and With a Direct Thrombin Inhibitor

Author(s) -

Giuseppe Cella,

Antonio Girolami,

Arthur A. Sasahara

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.25.3323

Subject(s) - medicine , heparin , thrombin , direct thrombin inhibitor , pharmacology , platelet activation , low molecular weight heparin , platelet , discovery and development of direct thrombin inhibitors , platelet factor 4 , warfarin , atrial fibrillation , dabigatran

To the Editor: We read with interest the article by Xiao and Theroux1 on “Platelet Activation With Unfractionated Heparin at Therapeutic Concentrations and Comparisons With a Low-Molecular-Weight Heparin and a Direct Thrombin Inhibitor.” They found that platelets of patients with unstable angina were hyperresponsive during treatment with unfractionated heparin (UFH). Moreover, aggregation to ADP and thrombin receptor agonist peptide (TRAP) was enhanced after addition of UFH ex vivo to blood of normal volunteers. In contrast, when a low-molecular-weight heparin …

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research