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SUMMARYCanine myocardial infarcts resulting from ligation of the left anterior descending coronary artery were localized in vivo by gamma scintigraphy following the intravenous injection of 131I anticardiac myosin antibody (Fab')2. The anteroapical location of the image was confirmed by demonstration of the blood pool with 99mTc sulfur colloid, and by subsequent imaging of the excised heart. The scintigram of the excised heart, following prior in vivo injection of 141Ce-microspheres, showed a region of diminished radioactivity near the apex which corresponded precisely to the region of 131I antibody (Fab')2% uptake. Well defined areas of 131I antibody (Fab')2 activity in the region of infarction were consistently imaged at 48 hours in animals in which the ligature occluding the coronary artery was released at 5 hours; 72 hours were at times required when coronary occlusion persisted throughout the experiment. In both reflow and persistent occlusion models, the concentration of 131I antibody (Fab')2 was inversely related to blood flow as determined from microsphere distribution in the region of infarction; though in areas of equivalent flow (0 to 20% of normal) the mean concentration ratio of antibody uptake to normal tissue was 20.7 ± 2.2 in the reflow model as compared to 11.4 ± 0.7 in the persistent occlusion model. A reduction in blood flow to the affected area of < 50% of normal did not result in the production of a localized scintigraphic image.

circulation

Experimental myocardial infarct imaging following intravenous administration of iodine-131 labeled antibody (Fab')2 fragments specific for cardiac myosin.