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We previously showed that the common Asn291Ser substitution in lipoprotein lipase is associated with elevated plasma triglyceride levels and a 2-fold increase in the risk of ischemic heart disease in women but not men. In this study, we tested the hypothesis that this substitution is also associated with an increased risk of ischemic cerebrovascular disease (ICVD).

A Common Mutation in Lipoprotein Lipase Confers a 2-Fold Increase in Risk of Ischemic Cerebrovascular Disease in Women but Not in Men