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Recent in vitro studies have demonstrated regional differences in electrophysiological properties of individual left ventricular muscle layers. Controversy exists on the relevance of these findings for the situation in vivo. Thus, this study was designed to determine whether the in vivo canine heart exhibits regional differences in left ventricular refractoriness and in the susceptibility to sodium and potassium channel blockers.

circulation

Rate- and Site-Dependent Effects of Propafenone, Dofetilide, and the New <i>I</i> <sub>Ks</sub> -Blocking Agent Chromanol 293b on Individual Muscle Layers of the Intact Canine Heart

Rate- and Site-Dependent Effects of Propafenone, Dofetilide, and the New I Ks -Blocking Agent Chromanol 293b on Individual Muscle Layers of the Intact Canine Heart

Rate- and Site-Dependent Effects of Propafenone, Dofetilide, and the New I _Ks -Blocking Agent Chromanol 293b on Individual Muscle Layers of the Intact Canine Heart