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Lima, Mariana Vidolin de. Strategies for pharmacological treatment of obesity in Brazil: Systematic review of literature for economic analysis using private perspective. 49 pages. Thesis (Master) Graduate Program in Applied Human Nutrition (FCF/FEA/FSP), University of Sao Paulo, Sao Paulo, 2017. Nowadays, obesity represents a significant public health problem in diverse countries, being positively associated to increased prevalence of chronic noncommunicable diseases. It imposes substantial burden to the population, resulting in losses regarding quality of life and productivity, in addition to increases in health system costs. Thus, the presente study proposed economic assessment of therapeutic strategies based on medication available in Brazilian market for treatment of obesity, using systematic literature review to identify health outcomes associated with direct costs estimation of the treatment alternatives. Systematic review of literature identified 17 studies on weight loss during obesity treatment with sibutramine, orlistat and liraglutide. Regarding economic assessment, cost-effectiveness ratios (RCE) of R$506.75; R$3,116.08 e R$2,176.45 per percentage point of weight loss for treatments with sibutramine, orlistat and liraglutide, respectively; indicating better effectiveness per cost for adoption of treatment with sibutramine. It is important highlight that medication for treatment of obesity requires individual assessment of the recommended therapy and monitoring of the patient’s adherence to treatment. Additionally, it is advisable to perform further research on other medication available, including monotherapy or combination therapy, along with analysis of maintenance of weight or weight regain after finishing treatment in the long run.

Estratégias para tratamento farmacológico da obesidade no Brasil: Revisão sistemática de literatura para análise econômica sob perspectiva privada