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Jesus FN. Consequences in the presence of ligature-induced periodontitis in rats on “in vitro” vasomotor response of mesenteric artery rings. [Masters thesis (Pharmacology)]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2014. Chronic destruction of periodontal attachment apparatus due to an intense inflammatory response to bacteria leads to a clinical condition known as periodontal disease. Periodontal pathogens can then translocate from the gingival sulcus and reach the bloodstream, and thus have peripheral effects. The periodontal pocket is also an important reservoir of inflammatory mediators, which can reach the bloodstream, and the periodontitis may have effects on organs and regions distant. Studies have also documented the relationship between periodontal disease and endothelial dysfunction, which was reversible by dental treatment. In our laboratory we are currently studying the vasomotor response "in vitro" of aortic rings from rats with ligature-induced periodontitis, and the preliminary results show significant increase in the contractile response of the rings to norepinephrine, when compared with the response of vessels obtained from control animals (Sham). Considering the importance of the effects of periodontal disease in remote organs, particularly the cardiovascular mentioned above, this study evaluated the influence of ligature-induced periodontitis in rats on the "in vitro" vascular reactivity of mesenteric artery vessels. The results showed that animals with ligature, during seven days, it showed decreased sensitivity of mesenteric artery to relaxation caused by exogenous NO and phosphodiesterase type V inhibitor. Moreover, results in significant increase in the transcription of the iNOS gene in the mesenteric artery, promoting even lower sensitivity of mesenteric artery to relaxation caused by SNP with iNOS inhibitor in the ligature group. Although, contractile factors derived from COX1 has the lowest participation of endothelium dependent vasorelaxation in the mesenteric artery from rat with ligature when compared to sham group. We conclude that in the ligature rat model may occur functional changes in smooth muscle, related to the NO-sGC-cGMP, and also seems to promote the production of mediators of vasorelaxant response to ACh related with hyperpolarization-mechanisms. Thus, studies with H2S donors, particularly slow-release compounds, should be performed in order to answer these questions that remain open.

Consequências da presença de periodontite induzida por ligadura em ratos sobre a resposta vaso motora in vitro de anéis de artéria mesentérica.