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RODRIGUES JUNIOR, C. F. Study of the molecular basis involved in the lipolytic effect of thyroid hormone in white adipose tissue. 60 f. Dissertation (Masters in Human Physiology) Institute of Biomedical Science, University of São Paulo. 2011. Thyroid hormones exert a recognized and potent lipolytic effect in white adipose tissue (TAB), yet little is known about the molecular mechanisms involved in these actions. It is known that the main effectors of the lipolytic action in this tissue is hormone-sensitive lipase (HSL) and lipase specific adipocyte triglycerides (ATGL), which hydrolyze triglycerides into fatty acids and glycerol. Other components involved in the lipolytic activity are the beta adrenergic receptors, which recognize their ligands to elevate intracellular cAMP content, with subsequent increased activity of PKA, and perilipin, proteins involving the fat droplet, forming a protective barrier against the action of HSL and ATGL, so that must be hydrolyzed to the HSL and ATGL lipolytic may exert its effect. It is known that thyroid hormones increase the expression of beta adrenergic receptors in various tissues, which may exert part of its lipolytic effect through this mechanism. With respect to the action of HT on the LHS, jobs are scarce and inconclusive, even less is known about its effect on ATGL and perilipin.Considering the importance of body fat for energy homeostasis and as a source of cytokines, many of which involved the installation of insulin resistance, and that the lipolytic actions of HT have been little explored aim of this study is to investigate in rats whether HT interfere with the expression of HSL, ATGL, Perilipin as well as beta adrenergic receptors in white adipose tissue, which could widen the field of knowledge of their lipolytic effects.

Estudo das bases moleculares envolvidas no efeito lipolítico do hormônio tireoidiano no tecido adiposo branco.