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This cross-sectional study was conducted among 73 healthcare workers in two laboratories in Bangui, using self administered questionnaire and scale grid to get information on knowledge and practice of management biomedical waste (BMW). Methods: Data were analyzed using SPSS software (version 20). Fisher chi-square test was used to investigate whether distributions of categorical variables differ from one another. Results: Findings from this study shows that; a gap in legal framework on BMW. Seventy percent of waste generated was infectious. Segregation and color coding was inappropriate. Only 29% of the services used safety boxes. Transport of BW is manual. About 64 % of respondents have not received training on BMW. 44 of 73 (60%) didn’t know certain diseases related to poor waste management and transmission routes. The surface technicians had significantly better knowledge about tetanus vaccine than the medical-technical staff (χ2 = 4.976, p=0.047). They had also a significantly higher risk of exposure to accidents due to waste handling than medical-technical (χ2=10.276, p=0.009). The 30-39 age group had a significantly higher risk of exposure to accidents related to the BMW compared to other ages groups (χ2=11.206, p=0.026).The National Laboratory personal has significantly higher knowledge about BCG and Meningitis vaccine than the Laboratory of Community Hospital personal (χ2=10.954, p=0.002 and χ2=4.304, p=0.05). Conclusion: BMW was poor. Collaboration between the City Hall and sanitation services with the support of partners will greatly reduce the risk of exposure faced by laboratory personnel and the population. Pan African Medical Journal 2016; 23

Management of biomedical waste in two medical laboratories in Bangui, Central African Republic