English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

AIM: To investigate the expression vascular endothelial growth factor (VEGF) and midkine (MK) and the i r s ign i f i cances in gas t r i c carcinoma. METHODS: Immunohistochemistry was performed to detect the expression of MK, VEGF and CD34 in gastric carcinoma (n = 64) and adjacent normal tissues (n = 20). RESULTS: The positive rates of MK and VEGF expression were significantly higher in gastric cancer tissues than those in the normal ones (76.6%, 79.7% vs 0, 15.0%, both P < 0.01). The expression of MK and VEGF had marked correlations with the invasion depth (χ = 7.111, P = 0.008; χ = 7.590, P = 0.006), lymph node metastasis (χ = 4.814, P = 0.028; χ = 6.207, P = 0.013), and clinical stages (χ = 13.971, P = 0.001; χ = 18.554, P = 0.000). The value of MVD in patients with positive MK expression was notably higher than that in ones with negative MK expression (31.745 ± 8.592 vs 24.680 ± 8.938, P < 0.01), and there was a positive correlation between MK and VEGF expression (χ = 4.447, P < 0.05). CONCLUSION: MK and VEGF may play synergistic roles in the growth, invasion and metastasis of gastric carcinoma, and their co-expression may be a useful indicator for the prognosis of gastric carcinoma.

Expression of midkine and vascular endothelial growth factor and their significances in gastric carcinoma