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AIM: To observe the effects of moxibustion at Zusanli and Liangmen on the expression of heat shock protein 70 (HSP70) in gastric mucosa in rats with stress-induced ulcer (SU), and explore the mechanism of moxibustion at the acupoints of Foot-Yangming meridian in preventing gastric mucosa from oxidative injury. METHODS: A total of 60 Sprague Dawley rats were randomly averagely divided into blank group, model group, Zusanli and Liangmen moxibustion group and non-moxibustion control group. After 7 days of pretreatment, the rats, except those in blank group, received water restraint stress (WRS) to induce stress ulcer. The gastric mucosal blood flow (GMBF) was measured by Laser Doppler Flowmetry (LDF) and the ulcer index (UI) was evaluated by Guth method. HSP70 expression and malondialdehyde (MDA) content in gastric mucosa were determined by immunohistochemical and thiobarbiturate technique. RESULTS: Moxibustion at Zusanli and Liangmen obviously relieved gastric mucosal injury in SU rats, the UI value was markedly lower than that in the model and control group (14.100 ± 5.425 vs 26.800 ± 9.807, 26.200 ± 7.729, P < 0.01). At the same time, Moxibustion at Zusanli and Liangmen significantly induced HSP70 higher expression (0.133 ± 0.035 vs 0.077 ± 0.057, 0.059 ± 0.038, P < 0.01), decreased MDA content (2.586 ± 0.252 μmol/L vs 3.906 ± 0.768, 3.464 ± 1.502 μmol/L, P < 0.05) and increased GMBF (279.827 ± 172.862 mL/min vs 139.489 ± 33.133, 141.512 ± 58.450 mL/min, P < 0.05). CONCLUSION: Moxibustion at Zusanli and Liangmen can prevent gastric mucosa from oxidative injury through inducing high expression of HSP70 and decreasing mucosal MDA content, with the relative specificity of acupoints.

shijie huaren xiaohua zazhi

Moxibustion at <i>Zusanli</i> and <i>Liangmen</i> prevents gastric mucosa from oxidation injury through inducing high expression of heat shock protein 70

Moxibustion at Zusanli and Liangmen prevents gastric mucosa from oxidation injury through inducing high expression of heat shock protein 70