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AIM: To observe the effect of Tongfu granules on the intestinal dysfunction of patients with multiple organ dysfunction syndromes (MODS). METHODS: Prospective, multi-center and randomized controlled trial was used in this study. A total of 140 patients selected from the ICU of 10 hospitals in Beijing were randomly divided into group A and B, treated with Mosapride Citrate and Tongfu granules, respectively. The experimental indexes, including peristaltic sound, the condition of pneumatosis and fluid in intestine (performing abdominal B-type ultrasound), serum endotoxin, diamine oxidase (DAO), D-lactic acid were observed at the 0, 48 hour, and the 7 day after treatment (or before death), respectively, and the scores for intestinal dysfunction were compared between the two groups according to Lushan meeting criteria in 1995. RESULTS: At the 7 day after treatment, the ratio of peristaltic sound (beat/min), the positive ratio of abdominal B-type ultrasound for pneumatosis and fluid, the levels of serum endotoxin, serum DAO, serum D-lactic acid, and intestinal dysfunction scores were significantly different between group A and B (2.29 ± 1.685 vs 3.62 ± 1.762, P < 0.01; 34.4% vs 13.5%, P < 0.05; 180 ± 30 EU/L vs 111 ± 21 EU/L, P < 0.05; 4.45 ± 1.67 μkat/L vs 3.17 ± 0.83 μkat/L, P < 0.01; 14.594 ± 2.022 mg/L vs 10.49 ± 4.185 mg/L, P < 0.05; 0.41 ± 0.12 vs 1.32 ± 0.14, P < 0.01). CONCLUSION: Tongfu granules can obviously promote intestinal motility and improve intestinal mucosal barrier function.

shijie huaren xiaohua zazhi

Efficacy of Tongfu granules in treatment of grastrointestinal dysfunction in patients with multiple organ dysfunction syndromes: an analysis of 140 cases