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Based on Freud’s personality theory, 839 nurses from 5 public hospitals in Shandong Province were selected by the convenience sampling method. A cross-sectional survey was conducted to investigate the correlation among resilience, work-family conflict (WFC), and anxiety (SAS). The purpose of this study was to explore the relationship among resilience, WFC, and SAS of these nurses and to provide evidence with reducing WFC and SAS for the nurses. The results showed that the total score of resilience, WFC, and SAS was  58.00 ± 18.27 ,  53.46 ± 13.29 , and  49.98 ± 14.73 , respectively. There was 47.68% of the nurses that had anxiety, and 10.97% of the nurses had severe anxiety. There were significant differences in the score of SAS among the length of service, self-perceived health status, confidence in nursing professional development, WFC, and resilience ( P &lt; 0.05 ). This study draws the following conclusions: the proportion of anxiety is high, and the level of resilience is lower than the domestic norm. Length of service, self-perceived health status, confidence in nursing professional development, WFC, and resilience were the important influencing factors of anxiety. It is suggested that hospital managers should pay attention to the mental health of nurses, take active intervention measures according to the influencing factors of SAS, improve nurses’ psychological resilience, reduce WFC and anxiety, improve nurses’ mental health and well-being, and ensure nursing safety.

A Study on the Relationship between Mental Resilience, Work-Family Conflict, and Anxiety of Nurses in Shandong, China