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We designed a case-control study and selected  LXR-α  rs7120118 C>T and  ABCA1  rs2230806 A>G polymorphisms to determine the correlation between these polymorphisms and diabetic kidney disease (DKD) susceptibility in a Chinese Han population. Three hundred DKD patients and 346 type 2 diabetes mellitus (DM) patients without kidney disease were recruited. Our results showed that rs7120118 was associated with DKD (genotype,  P  = .027; allele,  P  < .011). rs7120118 was associated with a higher risk of DKD under a dominant model adjustment by age and sex ( P  = .015) and an additive model ( P  = .040); rs2230806 was associated with a higher risk of DKD under an recessive model ( P  < .03); the combined effect of rs7120118 CC+rs2230806 GG genotype showed an association of DKD adjustment for age and sex ( P  = .009). In subgroup analysis of patients without hypercholesterolemia, the rs2230806 genotype frequencies were different between the two groups ( P  = .042). rs2230806 was associated with increased risk of DKD under a recessive model adjustment for age and sex ( P  = .013) and an additive model ( P  = .031). Our results suggest that  LXR-α  rs7120118 is significantly associated with a higher risk of DKD, and  ABCA1  rs2230806 is significantly associated with a higher risk of DKD without hypercholesterolemia in Chinese Han individuals.

journal of diabetes research

Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population