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Background   Fatigue is a common, distressing, and persistent symptom for patients with malignant tumor including colorectal cancer (CRC). Although studies of cancer-related fatigue (CRF) have sprung out in recent years, the pathophysiological mechanisms that induce CRF remain unclear, and effective therapeutic interventions have yet to be established.Methods   To investigate the effect of the traditional Chinese medicine YangZheng XiaoJi (YZXJ) on CRF, we constructed orthotopic colon cancer mice, randomly divided into YZXJ group and control (NS) group. Physical or mental fatigue was respectively assessed by swimming exhaustion time or suspension tail resting time. At the end of the experiment, serum was collected to measure the expression level of inflammatory factors by ELISA and feces to microbiota changes by 16s rDNA, and hepatic glycogen content was detected via the anthrone method.Result   The nutritional status of the YZXJ group was better than that of the control group, and there was no statistical difference in tumor weight. The swimming exhaustion times of YZXJ group and control group were (162.80 ± 14.67) s and (117.60 ± 13.42,  P  < 0.05) s, respectively; the suspension tail resting time of YZXJ group was shorter than that of the control group (49.85 ± 4.56) s and (68.83 ± 7.26) s,  P  < 0.05)). Serum levels of IL-1 β  and IL-6 in YZXJ group were significantly lower than the control group ( P  < 0.05). Liver glycogen in YZXJ group was (5.18 ± 3.11) mg/g liver tissue, which was significantly higher than that in control group (2.95 ± 2.06) mg/g liver tissue ( P  < 0.05). At phylum level, increased abundance of  Bacteroidetes, Verrucomicrobia, Actinobacteria,  and  Cyanobacteria  and decreased  Proteobacteria  in YZXJ group emerged as the top differences between the two groups, and the  Firmicutes/Bacteroidetes  ratio was decreased in YZXJ group compared to the control group. At genus level, the abundance of  Parabacteroides , unidentified  Saprospiraceae,  and  Elizabethkingia  which all belong to phylum  Bacteroidetes  were increased, while  Arcobacter, Marinobacter, Alkanindiges, Sulfuricurvum, Haliangium , and  Thiobacillus  in phylum  Proteobacteria  were decreased after YZXJ intervention. YZXJ can also increase  Pirellula ,  Microbacterium,  and  Alpinimonas  and decrease  Rubrobacter  and  Iamia .Conclusion   YZXJ may reduce the physical and mental fatigue caused by colorectal cancer by inhibiting inflammatory reaction, promoting hepatic glycogen synthesis, and changing the composition of intestinal microbiota.

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer