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Six new titanocene compounds have been isolated and characterised. These compounds were synthesised from their fulvene precursors using Super Hydride (LiBEt 3 H) followed by transmetallation with titanium tetrachloride to yield the corresponding titanocene dichloride derivatives. These complexes are bis-[((1-methyl-3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride  (5a) , bis-[((5-methoxy-1-methyl,3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride  (5b) , bis-[((1-methyl,3-diethylaminomethyl)indol-4-yl)methylcyclopentadienyl] titanium (IV) dichloride  (5c) , bis-[((5-bromo-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride  (5d) , bis-[((5-chloro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride  (5e) , and bis-[((5-fluoro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride  (5f) . All six titanocenes  5a–5f  were tested for their cytotoxicity through MTT-based  in vitro  tests on CAKI-1 cell lines using DMSO and Soluphor P as solubilising agents in order to determine their IC 50  values. Titanocenes  5a–5f  were found to have IC 50  values of 10 (±2), 21 (±3), 29 (±4), 140 (±6), and 450 (±10)  μ M when tested using DMSO.

Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives