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Cell-surface interactions play a crucial role for biomaterial application in orthopaedics.It is evident that not only the chemical composition of solid substances influence cellular adherence,migration, proliferation and differentiation but also the surface topography of a biomaterial.The progressive application of nanostructured surfaces in medicine has gained increasing interestto improve the cytocompatibility and osteointegration of orthopaedic implants. Therefore, theunderstanding of cell-surface interactions is of major interest for these substances. In this review,we elucidate the principle mechanisms of nano- and microscale cell-surface interactions in vitro fordifferent cell types onto typical orthopaedic biomaterials such as titanium (Ti),cobalt-chrome-molybdenum (CoCrMo) alloys, stainless steel (SS), as well as synthetic polymers(UHMWPE, XLPE, PEEK, PLLA). In addition, effects of nano- and microscaled particles and theirsignificance in orthopaedics were reviewed. The significance for the cytocompatibilityof nanobiomaterials is discussed critically

Significance of Nano- and Microtopography for Cell-Surface Interactions in Orthopaedic Implants