English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Greater H +  retention in animal models of chronic kidney disease (CKD) mediates faster glomerular filtration rate (GFR) decline and dietary H +  reduction slows eGFR decline in CKD patients with reduced eGFR and H +  retention due to the high acid (H + ) diets of developed societies. We examined if H +  retention in CKD is inversely associated with estimated GFR (eGFR) using cross-sectional and longitudinal analysis of individuals with CKD stage 1 (&gt;90 ml·min − 1 ·1.73 m −2 ), CKD stage 2 (60–89 ml/min per 1.73 m 2 ), and CKD stage 3 (30–59 ml·min − 1 ·1.73 m −2 ) eGFR. H +  retention was assessed using the difference between observed and expected plasma total CO 2  2 h after 0.5 meq/kg body wt oral NaHCO 3 . H +  retention was higher in CKD 2 vs. CKD 1 ( P &lt; 0.01) and in CKD 3 vs. CKD 2 ( P &lt; 0.02) at baseline and 5 yr, and was higher in CKD 2 vs. CKD 1 ( P &lt; 0.01) at 10 yr. All groups had lower eGFR at subsequent time points ( P &lt; 0.01) but H +  retention was not different among the three time points for CKD 1. By contrast, eGFR decrease was associated with higher H +  retention in CKD 2 at 5 yr ( P = 0.04) and 10 yr ( P &lt; 0.01) and with higher H +  retention in CKD 3 at 5 yr ( P &lt; 0.01). Yearly eGFR decline rate was faster in CKD 2 vs. CKD 1 ( P &lt; 0.01) and in CKD 3 vs. CKD 2 ( P &lt; 0.01). The data show that H +  retention is inversely associated with eGFR, with faster eGFR decline, and support the need for greater dietary H +  reduction therapy for CKD individuals with lower eGFR.

Acid retention in chronic kidney disease is inversely related to GFR