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it's been over two decades since a captivating search for what powers ion transport in the insect Malpighian tubule culminated in the discovery that the vacuolar-type H+ ATPase, and not the Na+-K+-ATPase, drives transepithelial transport of electrolytes ([8][1], [18][2]) and probably also organic

american journal of physiology. regulatory, integrative and comparative physiology/american journal of physiology. regulatory, integrative, and comparative physiology

Ca2+and cAMP signaling pathways interact to increase the diuretic effect of serotonin in Malpighian tubules of the kissing bug. Focus on “Serotonin triggers cAMP- and PKA-1-mediated intracellular calcium waves in Malpighian tubules ofRhodnius prolixus”