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First, a novel computational model simulating arterial hemodynamics during flow-mediated dilation (FMD) was proposed. Second, the model was used to explain why FMD may be influenced by endothelium-independent factors, showing that FMD results are 1) partly masked by the vasoconstriction due to the change in transmural pressure and 2) affected by physiological factors (i.e., arterial stiffness and arterial blood pressure) that are difficult to eliminate due to their multiple interactions.

american journal of physiology. heart and circulatory physiology

An in silico simulation of flow-mediated dilation reveals that blood pressure and other factors may influence the response independent of endothelial function