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Intrauterine growth restriction (IUGR) impairs infant well being and increases susceptibility to later-in-life diseases for mother and child. Our study reveals a novel role for AMPK in vasodilating the myometrial artery (MA) from women residing at high altitude (&gt;2,500 m) with appropriate for gestational age pregnancies but not in IUGR pregnancies at any altitude.

AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies