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the renin-angiotensin system (RAS) is important in the physiological and pathophysiological regulation of blood pressure and cardiovascular function. The (pro)renin receptor (PRR, also called ATP6AP2) is one of the newer member of the RAS ([10][1], [20][2]). Emerging evidence indicates that the PRR

ANG II-independent prorenin/(pro)renin receptor signaling pathways in the central nervous system