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We study inclusive heavy quark and exclusive heavy quark pair production inpp, pA and AA interactions. Intrinsic transverse momentum is introduced in ppinteractions. Nuclear effects, limited to $k_T$ broadening and nuclearshadowing, are introduced in pA and AA interactions. The nuclear dependence isstudied over a range of energies, both in fixed target and collider setups.Comment: 69 pages, 42 .eps figures, to appear in the Proceedings of the Hard  Probe Collaboratio

The A-Dependence of Open Charm and Bottom Production