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Methods are described in the framework of light-cone expansion which allowone to determine the Cabibbo-Kobayashi-Maskawa matrix elements |V_ub| and|V_cb| from measurements of the differential decay rates as a function of thescaling variables in the inclusive semileptonic decays of B mesons. By thesemodel-independent methods the dominant hadronic uncertainties can be avoidedand the B -> X_u\ell\nu decay can be very efficiently differentiated from the B-> X_c\ell\nu decay, which may lead to precise determinations of |V_ub| and|V_cb|.Comment: 11 pages, 2 figures, version as published in Mod. Phys. Lett. A, more  discussion, references added, title chang

DETERMINATIONS OF |Vub| AND |Vcb| FROM MEASUREMENTS OF B→ Xu,cℓν DIFFERENTIAL DECAY RATES

DETERMINATIONS OF |V_ub| AND |V_cb| FROM MEASUREMENTS OF B→ X_u,cℓν DIFFERENTIAL DECAY RATES