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We discuss the isospin effect on the possible phase transition from hadronicto quark matter at high baryon density and finite temperatures. Thetwo-Equation of State (Two-EoS) model is adopted to describe the hadron-quarkphase transition in dense matter formed in heavy-ion collisions. For the hadronsector we use Relativistic Mean Field (RMF) effective models, already tested onheavy ion collision (HIC). For the quark phase we consider various effectivemodels, the MIT-Bag static picture, the Nambu--Jona-Lasinio (NJL) approach withchiral dynamics and finally the NJL coupled to the Polyakov-loop field (PNJL),which includes both chiral and (de)confinement dynamics. The idea is to extractmixed phase properties which appear robust with respect to the modeldifferences. In particular we focus on the phase transitions of isospinasymmetric matter, with two main results: i) an earlier transition to a mixedhadron-quark phase, at lower baryon density/chemical potential with respect tosymmetric matter; ii) an "Isospin Distillation" to the quark component of themixed phase, with predicted effects on the final hadron production. Possibleobservation signals are suggested to probe in heavy-ion collision experimentsat intermediate energies, in the range of the NICA program.

Probing the hadron-quark mixed phase at high isospin and baryon density - Sensitive observables