English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Inositol is an essential nutrient with important structural and signaling functions in eukaryotes. Its role in microbial pathogenesis has been reported in fungi, protozoans, and eubacteria. In a recent article, Porollo et al. [mBio 5(6):e01834-14, 2014, doi:10.1128/mBio.01834-14] demonstrated the importance of inositol metabolism in the development and viability of Pneumocystis species — obligate fungal pathogens that remain unculturable in vitro. To understand their obligate nature, the authors used innovative comparative genomic approaches and discovered that Pneumocystis spp. are inositol auxotrophs due to the lack of inositol biosynthetic enzymes and that inositol insufficiency is a contributing factor preventing fungal growth in vitro. This work is in accord with other studies suggesting that inositol plays a conserved role in microbial pathogenesis. Inositol uptake and metabolism therefore may represent novel antimicrobial drug targets. Using comparative genomics to analyze meta-bolic pathways offers a powerful tool to gain new insights into nutrient utilization in microbes, especially obligate pathogens. Microorganisms quickly adapt to a changing environment bysensing and responding to environmental cues, such as nu-trients. Understanding how pathogens sense and utilize nutrients during pathogen-host interactions provides important insights into how to control diseases caused by thesemicrobes. Inositol is a nutrient that plays important structural and signaling roles in both mammalian hosts and fungal pathogens, in particular b

mbio

Comparative Genomics of <i>Pneumocystis</i> Species Suggests the Absence of Genes for <i>myo-</i> Inositol Synthesis and Reliance on Inositol Transport and Metabolism

Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo- Inositol Synthesis and Reliance on Inositol Transport and Metabolism