Open AccessPenicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
Author(s) -
P. Hinchliffe,
C.L. Tooke,
Christopher R. Bethel,
Benlian Wang,
Christopher P. Arthur,
Kate J. Heesom,
Stuart Shapiro,
Daniela Schlatzer,
Krisztina M. Papp-Wallace,
Robert A. Bonomo,
James Spencer
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.01793-21
Subject(s) - chemistry , stereochemistry , tazobactam , residue (chemistry) , serine , epimer , enzyme , antibiotics , antibiotic resistance , biochemistry , imipenem