English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Colistin is an ultimate line of refuge against multidrug-resistant Gram-negative pathogens. Very recently, the emergence of plasmid-mediated  mcr-1  colistin resistance has become a great challenge to global public health, raising the possibility that dissemination of the  mcr-1  gene is underestimated and diversified. Here, we report three cases of plasmid-carried MCR-1 colistin resistance in isolates from gut microbiota of diarrhea patients. Structural and functional analyses determined that the colistin resistance is conferred purely by the single  mcr-1  gene. Genetic and sequence mapping revealed that  mcr-1 -harbouring plasmid reservoirs are present in diversity. Together, the data represent the first evidence of diversity in  mcr-1 -harbouring plasmid reservoirs of human gut microbiota.

Diversified mcr-1 -Harbouring Plasmid Reservoirs Confer Resistance to Colistin in Human Gut Microbiota