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Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.

Sustained CD8 + T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans

Sustained CD8 ⁺ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans