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In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional determinant. Mutation of distal leucines (499)L and (502)L (LL mutant) caused an inhibitory effect on Alix-dependent SIV(smE543) release that was quantitatively similar to that observed following disruption of the type 3 L domain or RNA interference (RNAi) depletion of Alix. Similar results were obtained with the SIV(mac239) LL mutant. Thus, distal leucines are key determinants of SIV(smE543) and SIV(mac239) type 3 L domains.

journal of virology

Distal Leucines Are Key Functional Determinants of Alix-Binding Simian Immunodeficiency Virus SIV <sub>smE543</sub> and SIV <sub>mac239</sub> Type 3 L Domains

Distal Leucines Are Key Functional Determinants of Alix-Binding Simian Immunodeficiency Virus SIV smE543 and SIV mac239 Type 3 L Domains

Distal Leucines Are Key Functional Determinants of Alix-Binding Simian Immunodeficiency Virus SIV _smE543 and SIV _mac239 Type 3 L Domains