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The varicella-zoster virus (VZV) ORF61 protein is necessary for normal replicationin vitro and virulence in human skin xenografts in the severe combined immunodeficiency mouse modelin vivo . These experiments identify a hydrophobic domain that mediates ORF61 self-interaction. While not needed to inhibit host cell defenses, disruption of this domain (residues 250 to 320) severely impairs VZV growth, transactivation of the immediate early 63 and glycoprotein E genes, and the pathogenesis of VZV skin infectionin vivo .

Identification of a Hydrophobic Domain in Varicella-Zoster Virus ORF61 Necessary for ORF61 Self-Interaction, Viral Replication, and Skin Pathogenesis