Open AccessProtective Effects of Broadly Neutralizing Immunoglobulin against Homologous and Heterologous Equine Infectious Anemia Virus Infection in Horses with Severe Combined Immunodeficiency
Author(s) -
Sandra Taylor,
Steven R. Leib,
Wuwei Wu,
R. Nelson,
Susan Carpenter,
Robert H. Mealey
Publication year - 2011
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00077-11
Subject(s) - equine infectious anemia , heterologous , biology , virology , neutralizing antibody , lentivirus , neutralization , antibody , virus , immunology , viral disease , genetics , gene
Using the equine infectious anemia virus (EIAV) lentivirus model system, we previously demonstrated protective effects of broadly neutralizing immune plasma in young horses (foals) with severe combined immunodeficiency (SCID). However,in vivo selection of a neutralization-resistant envelope variant occurred. Here, we determined the protective effects of purified immunoglobulin with more potent broadly neutralizing activity. Overall, protection correlated with the breadth and potency of neutralizing activityin vitro . Four of five SCID foals were completely protected against homologous challenge, while partial protection occurred following heterologous challenge. These results support the inclusion of broadly neutralizing antibodies in lentivirus control strategies.