Open AccessDiscovery of the Neutralizing Epitope Common to Influenza B Virus Victoria Group Isolates in Japan
Author(s) -
Naoko Nakagawa,
Jun Suzuoki,
Ritsuko Kubota,
Shinzo Kobatake,
Yoshinobu Okuno
Publication year - 2006
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.44.4.1564-1566.2006
Subject(s) - virology , virus , orthomyxoviridae , epitope , influenza a virus , biology , influenzavirus b , microbiology and biotechnology , antibody , immunology
Monoclonal antibody 9B2 possesses hemagglutination inhibition activity against all the 2002/2003 influenza B virus Victoria group isolates in Kobe, Japan, as well as representative strains isolated between 1987 and 1997. The 9B2 epitope localizes three-dimensionally in the vicinity of antigenic site A of the hemagglutinin molecule, and amino acid substitutions in this region affected the binding of 9B2.