Open AccessNationwide Survey of In Vitro Activities of Itraconazole and Voriconazole against Clinical Aspergillus fumigatus Isolates Cultured between 1945 and 1998
Author(s) -
Paul E. Verweij,
D. T. A. Te Dorsthorst,
Antonius J. M. M. Rijs,
H. G. de Vries-Hospers,
Jacques F. Meis
Publication year - 2002
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.40.7.2648-2650.2002
Subject(s) - voriconazole , itraconazole , aspergillus fumigatus , microbiology and biotechnology , aspergillus , aspergillosis , in vitro , biology , fungi imperfecti , medicine , antifungal , immunology , genetics
The isolates in a collection of 170 Aspergillus fumigatus isolates recovered from 114 patients and 21 different medical centers in The Netherlands over a period of 53 years were tested for the presence of resistance to itraconazole and voriconazole according to the guidelines of NCCLS document M38-P and by the E-test. Three isolates were highly resistant to itraconazole, and voriconazole MICs were low for all isolates.