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Data from sequence analysis, genotyping by restriction fragment length polymorphism in the 5' noncoding region, and NS4 serotyping of the sera of 20 patients with chronic hepatitis C virus infection have shown 100% concordance, while core-based methods and a line probe assay have shown several missing or wrong results.

journal of clinical microbiology

Concordance of hepatitis C virus typing methods based on restriction fragment length polymorphism analysis in 5' noncoding region and NS4 serotyping, but not in core PCR or a line probe assay