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The genetic analysis of high-level mupirocin resistance (Hi-Mupr ) in aStaphylococcus pseudintermedius isolate from a dog is presented. The Hi-Mupr ileS2 gene flanked by a novel rearrangement of directly repeated insertion sequence IS257 elements was located, together with the aminoglycoside resistanceaacA-aphD determinant, on a conjugative plasmid related to the pSK41/pGO1 family plasmids.

Molecular Characterization of High-Level Mupirocin Resistance in Staphylococcus pseudintermedius