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Mycoplasma hyorhinis has been implicated in a variety of swine diseases. However, little is known about the hemolytic capabilities ofMycoplasma species in general orM. hyorhinis in particular. In this study, we show thatM. hyorhinis possesses beta-hemolytic activity which may be involved in the invasion process.M. hyorhinis also possesses antagonistic cooperativity (reverse CAMP phenomenon) withStaphylococcus aureus beta-hemolysis, resulting in the protection of erythrocytes from the beta-hemolytic activity ofS. aureus (reverse CAMP). The reversed CAMP phenomenon has been attributed to phospholipase D (PLD) activity.In silico analysis of theM. hyorhinis genome revealed the absence of thepld gene but the presence of thecls gene encoding cardiolipin synthetase, which contains two PLD active domains. The transformation ofMycoplasma gallisepticum that has neither thecls gene nor the reverse CAMP phenomenon with thecls gene fromM. hyorhinis resulted in the reverse CAMP phenomenon, suggesting for the first time that reverse CAMP can be induced by cardiolipin synthetase.

journal of clinical microbiology

Cardiolipin Synthetase Is Involved in Antagonistic Interaction (Reverse CAMP Phenomenon) of Mycoplasma Species with Staphylococcus aureus Beta-Hemolysis