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Cook, Thomas M. , (Sterling-Winthrop Research Institute, Rensselaer, N.Y.),William A. Goss, and William H. Deitz . Mechanism of action of nalidixic acid onEscherichia coli . V. Possible mutagenic effect. J. Bacteriol.91: 780–783. 1966.—With a streptomycin-dependent organism,Escherichia coli ATCC 11143, it has been shown that exposure to nalidixic acid, under conditions permitting some bactericidal action, results in an increased number of streptomycin-independent bacteria among the survivors. This effect is evident only with proliferating cultures, and is related to the concentration of nalidixic acid and the duration of exposure.

Mechanism of Action of Nalidixic Acid on Escherichia coli V. Possible Mutagenic Effect