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During the course of our studies on the mechanism of action of the mutagen ethyl sulfate (Strauss and Okubo, 1960) we decided to test the effect of incubation in buffers of various composition after treatment with the mutagenic agent. It was found that incubation of treated cells in citrate had a lethal effect and it was decided to investigate the reason for this lethality. As a result of the investigations to be described below, we have concluded that treatment with ethyl sulfate leads to changes in the permeability of the treated cells which permit the ready removal of intracellular ions by chelating agents. The removal of these ions, particularly magnesium ion, leads to breakdown of the intracellular nucleic acid and to cell death.

PRODUCTION OF A PERMEABILITY DEFECT INESCHERICHIA COLIBY THE MUTAGENIC ALKYLATING AGENT, ETHYL SULFATE