Open AccessMicroarray Analysis of the Osmotic Stress Response in Pseudomonas aeruginosa
Author(s) -
Arden Aspedon,
Kelli L. Palmer,
Marvin Whiteley
Publication year - 2006
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.188.7.2721-2725.2006
Subject(s) - biology , osmotic shock , pseudomonas aeruginosa , osmotic concentration , osmoprotectant , secretion , two component regulatory system , microbiology and biotechnology , gene , microarray analysis techniques , genetics , bacteria , biochemistry , gene expression , mutant , proline , amino acid
Transcriptional profiling ofPseudomonas aeruginosa grown under steady-state hyperosmotic stress conditions showed an up-regulation of genes associated with osmoprotectant synthesis, putative hydrophilins, and the type III secretion system with associated cytotoxins. A large number of regulatory genes, including several two-component systems not previously known to be influenced by osmolarity, were differentially expressed byP. aeruginosa in immediate response to hyperosmotic shock.