Open AccessCharacterization of a Bacillus subtilis Thermosensitive Teichoic Acid-Deficient Mutant: Gene mnaA ( yvyH ) Encodes the UDP- N -Acetylglucosamine 2-Epimerase
Author(s) -
Blazenka Soldo,
Vladimir Lazarević,
Harold M. Pooley,
Dimitri Karamata
Publication year - 2002
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.184.15.4316-4320.2002
Subject(s) - teichoic acid , bacillus subtilis , biology , mutant , cell wall , biochemistry , gene , cell envelope , bacillaceae , microbiology and biotechnology , bacteria , peptidoglycan , escherichia coli , genetics
The Bacillus subtilis thermosensitive mutant ts-21 bears two C-G-->T-A transitions in the mnaA gene. At the nonpermissive temperature it is characterized by coccoid cell morphology and reduced cell wall phosphate content. MnaA converts UDP-N-acetylglucosamine into UDP-N-acetylmannosamine, a precursor of the teichoic acid linkage unit.