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Synthesis of the OmpF porin ofEscherichia coli is regulated in response to environmental and growth phase signals. In order to identify constituents of the various regulatory pathways involved in modulatingompF transcriptional expression, transposon insertion mutagenesis was performed and mutations that increasedompF′-lacZ activity were identified as previously described. Mutations mapping to a previously identified gene of unknown function,lrhA , were obtained. We found that LrhA, a LysR homolog, functions as a regulatory component in the RpoS-dependent growth phase repression ofompF . In addition to altered growth phase regulation ofompF , theselrhA mutants have pleiotropic stationary-phase defects as a result of decreased RpoS levels. We provide evidence that LrhA promotes degradation of RpoS by functioning within a genetic pathway that includes the response regulator SprE and the ClpXP protease. LrhA functions upstream of the other components in the pathway and appears to modulate the activity of SprE.

The LysR Homolog LrhA Promotes RpoS Degradation by Modulating Activity of the Response Regulator SprE