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ScaA lipoprotein inStreptococcus gordonii is a member of the LraI family of homologous polypeptides found among streptococci, pneumococci, and enterococci. It is the product of the third gene within thescaCBA operon encoding the components of an ATP-binding cassette (ABC) transporter system. Inactivation ofscaC (ATP-binding protein) orscaA (substrate-binding protein) genes resulted in both impaired growth of cells and &gt;70% inhibition of54 Mn2+ uptake in media containing &lt;0.5 μM Mn2+ . In wild-type andscaC mutant cells, production of ScaA was induced at low concentrations of extracellular Mn2+ (&lt;0.5 μM) and by the addition of ≥20 μM Zn2+ . Sca permease-mediated uptake of54 Mn2+ was inhibited by Zn2+ but not by Ca2+ , Mg2+ , Fe2+ , or Cu2+ . Reduced uptake of54 Mn2+ bysca mutants and by wild-type cells in the presence of Zn2+ was abrogated by the uncoupler carbonylcyanidem -chlorophenylhydrazone, suggesting that Mn2+ uptake under these conditions was proton motive force dependent. The frequency of DNA-mediated transformation was reduced &gt;20-fold insca mutants. The addition of 0.1 mM Mn2+ to the transformation medium restored only partly the transformability of mutant cells, implying an alternate role for Sca proteins in the transformation process. Cells ofsca mutants were unaffected in other binding properties tested and were unaffected in sensitivity to oxidants. The results show that Sca permease is a high-affinity mechanism for the acquisition of Mn2+ and is essential for growth of streptococci under Mn2+ -limiting conditions.

journal of bacteriology

The Adhesion-Associated sca Operon in Streptococcus gordonii Encodes an Inducible High-Affinity ABC Transporter for Mn 2+ Uptake