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The initiation of growth of a polyaromatic auxotrophic mutant ofSaccharomyces cerevisiae was inhibited by several amino acids, whereas growth of the parent prototroph was unaffected. A comparative investigation of amino acid transport in the two strains employing14 C-labeled amino acids revealed that the transport of amino acids inS. cerevisiae was mediated by a general transport system responsible for the uptake of all neutral as well as basic amino acids. Both auxotrophic and prototrophic strains exhibited stereospecificity forl -amino acids and aKm ranging from 1.5 × 10−5 to 5.0 × 10−5 M. Optimal transport activity occurred at pH 5.7. Cycloheximide had no effect on amino acid uptake, indicating that protein synthesis was not a direct requirement for amino acid transport. Regulation of amino acid transport was subject to the concentration of amino acids in the free amino acid pool. Amino acid inhibition of the uptake of the aromatic amino acids by the aromatic auxotroph did not correlate directly with the effect of amino acids on the initiation of growth of the auxotroph but provides a partial explanation of this effect.

Amino Acid Transport in a Polyaromatic Amino Acid Auxotroph of Saccharomyces cerevisiae