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Mutations at theapf locus selectively depress the activity of a number of distinct amino acid permeases inSaccharomyces cerevisiae . The activity of the general amino acid permease and specific amino acid permeases is decreased, but the uptake of pyrimidines and adenine is unaffected. Mutations at theapf locus are allelic to theaap mutation isolated by Surdin et al. Amino acid uptake is normal in a heterozygous diploid (apf /+) and in a tetraploid strain with only one functional allele at theapf locus.

Mutation Affecting Activity of Several Distinct Amino Acid Transport Systems in Saccharomyces cerevisiae