Open AccessOsteopontin Participates in Th1-Mediated Host Resistance against Nonlethal Malaria ParasitePlasmodium chabaudi chabaudiInfection in Mice
Author(s) -
Yoshimasa Maeno,
Satoru Nakazawa,
Naoki Yamamoto,
Masanori Shinzato,
Shigeo Nagashima,
Kumiko Tanaka,
Jun Sasaki,
Susan R. Rittling,
David T. Denhardt,
Toshimitsu Uede,
Koki Taniguchi
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.74.4.2423-2427.2006
Subject(s) - plasmodium chabaudi , biology , parasite hosting , malaria , plasmodium (life cycle) , immunity , immunology , virology , host resistance , host (biology) , plasmodium falciparum , parasitemia , immune system , ecology , world wide web , computer science
Osteopontin (OPN) knockout mice (OPN-KO mice) died ofPlasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.